Globalisation, Competitive Governments, and Constitutional Choice in Europe

The traditional school of economic policy analysis predicts that globalisation will give rise to predatory competition between the governments of the European nation states. The consequence is anticipated to be a marked reduction in, if not the destruction of, the benevolent Welfare State. The objective of this contribution is to present the main arguments that have led us to believe that, this traditional literature notwithstanding, a European constitution should not restrict but rather should encourage horizontal and vertical governmental competition. In our view the European political order, in defining the relationship among member states and also the relationship between the member states and the EU, ought to be inspired by what we know about competition in the commercial sphere.globalisation, globalization

Intergovernmental equalization grants: some fundamental principles.

Propositions related to intergovernmental equalization grants are always implicitly or explicitly derived from one model of government or another. The paper assumes that governments are competitive organisms. In such a frame of reference, equalization payments serve to insure that all the units in a decentralized governmental system have a chance to share in the benefits of competition. In other words, equalization payments are stabilization instruments. As such they will generally have an effect on the interpersonal distribution of income, but they are not motivated by that effect. The paper also argues that economic globalization increases the need for equalization grants.

Explaining differences in environmental governance patterns between Canada, Italy and the United States.

The objective of the paper is to formulate a hypothesis that can help explain the different patterns of environmental governance in three countries: Canada and the United States (both federal states) and Italy (a decentralized unitary state). To that effect, we will make use of what is a robust theory of the assignment of powers in federal and decentralized unitary states on the role of competition as a driving force in shaping these assignments. The differing patterns of environmental governance we wish to explain are that most environmental policies are enacted and implemented by the national government in the United States, by provincial governments in Canada, and by both national and regional governments in Italy.

Protective Action of Resveratrol in Human Skin: Possible Involvement of Specific Receptor Binding Sites

Background: Resveratrol is a plant-derived polyphenol with purported protecting action on various disorders associated with aging. It has been suggested that resveratrol could exert its protective action by acting on specific plasma membrane polyphenol binding sites (Han Y.S., et al. (2006) J Pharmacol Exp Ther 318:238–245). The purpose of this study was to investigate, in human skin, the possible existence of specific binding sites that mediate the protective action of resveratrol. Methods and Findings: Using human skin tissue, we report here the presence of specific [ 3 H]-resveratrol binding sites (KD = 180 nM) that are mainly located in the epidermis. Exposure of HaCaT cells to the nitric oxide free radical donor sodium nitroprusside (SNP; 0.3–3 mM) resulted in cell death which was reduced by resveratrol (EC50 = 14.7 mM), and to a much lesser extent by the resveratrol analogue piceatannol (EC 50 =95 mM) and epigallocatechin gallate (EC 50 =200 mM), a green-tea derived polyphenol. The protective action of resveratrol likely relates to its anti-apoptotic effect since at the same range of concentration it was able to reduce both the number of apoptotic cells as well as mitochondrial apoptotic events triggered by SNP. Conclusion: Taken together, these findings suggest that resveratrol, by acting on specific polyphenol binding sites i

Controlling the Circadian Clock with High Temporal Resolution through Photodosing

Circadian clocks, biological timekeepers that are present in almost every cell of our body, are complex systems whose disruption is connected to various diseases. Controlling cellular clock function with high temporal resolution in an inducible manner would yield an innovative approach for the circadian rhythm regulation. In the present study, we present structure-guided incorporation of photoremovable protecting groups into a circadian clock modifier, longdaysin, which inhibits casein kinase I (CKI). Using photodeprotection by UV or visible light (400 nm) as the external stimulus, we have achieved quantitative and light-inducible control over the CKI activity accompanied by an accurate regulation of circadian period in cultured human cells and mouse tissues, as well as in living zebrafish. This research paves the way for the application of photodosing in achieving precise temporal control over the biological timing and opens the door for chronophotopharmacology to deeper understand the circadian clock system

Dynamics of brain networks in aesthetic appreciation

Neuroimage experiments have been essential for identifying active brain networks. During cognitive tasks as in, e.g., aesthetic appreciation, such networks include regions that belong to the default mode network (DMN). Theoretically, DMN activity should be interrupted during cognitive tasks demanding attention, as is the case for aesthetic appreciation. Analyzing the functional connectivity dynamics along three temporal windows and two conditions, beautiful and not beautiful stimuli, here we report experimental support for the hypothesis that aesthetic appreciation relies on the activation of two different networks, an initial aesthetic network and a delayed aesthetic network, engaged within distinct time frames. Activation of the DMN might correspond mainly to the delayed aesthetic network. We discuss adaptive and evolutionary explanations for the relationships existing between the DMN and aesthetic networks and offer unique inputs to debates on the mind/brain interaction